Cost-effectiveness of migraine prevention: the case of topiramate in the UK
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چکیده
Sources searched to identify primary studies The base-case monthly migraine frequency, the probabilities of response (>= 75%, 50 75% and <50% reduction in migraine frequency) and the treatment discontinuation rate were derived from pooled data from three randomised, double-blinded, placebo-controlled trials (RCTs) of TPM (Brandes et al. 2004, Diener et al. 2004 and Silberstein et al. 2004, see 'Other Publications of Related Interest' below for bibliographic details). The average reduction in migraine
منابع مشابه
Cost-effectiveness of antiepileptic drugs in migraine prophylaxis.
OBJECTIVE To analyze the cost-effectiveness of antiepileptics in migraine prophylaxis. METHODS A cost-effectiveness analysis was performed using efficacy data from three recent, double-blind, placebo-controlled, clinical trials of antiepileptic drugs studied for migraine prevention and cost data. Two measures of cost-effectiveness were used: cost per headache prevented and the cost-equivalent...
متن کاملTopiramate: the evidence for its therapeutic value in the prevention of migraine
INTRODUCTION Preventive therapy is recommended in patients with migraines frequent and/or severe enough to interfere with daily life, and/or with an inadequate response to acute therapy (26-43% of patients with migraine in a recent US survey). Preventive treatments include beta blockers, amitriptyline, and antiepileptics (sodium valproate, gabapentin), but these may have significant adverse eff...
متن کاملTopiramate: Safety and Efficacy of its Use in the Prevention and Treatment of Migraine
Migraine headaches are typically episodic in nature and may affect nearly 10% of the population. In addition to treatment, prevention of subsequent episodes or progression to a chronic migraine state is an important therapeutic area. Topiramate is a centrally acting medication approved for both the prevention of seizures and migraine headache. At this time, the exact mechanism of how topiramate...
متن کاملبررسی میزان اثربخشی توپیرامات در بهبود سردردهای میگرنی
Abstract Background: Several studies suggest improvements in quality of life in migraine patients with topiramate. MIDAS (Migraine Disability Assessment) and HIT6 (Headache Impact Test) are two questionnaires for evaluating migraine severity. The aim of this study was to assess the efficacy of Topiramate 100 mg/day in control and prophylaxis of migraine headache. Materials and methods: Eigh...
متن کاملThe development or exacerbation of eating disorder symptoms after topiramate initiation.
The Food and Drug Administration recently approved topiramate for migraine prevention in adolescents. Given the well-established appetite-suppressant side effects of topiramate, as well as data suggesting a potential comorbidity between migraine and eating disorders, susceptible young migraine patients may be at a greater risk for the development or worsening of eating disorder symptoms with to...
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